Na+/H+ metabolic activity in the thrombocytes of spontaneously hypertensive rats
Markov, K.M.; Pinelis, V.G.; Kudinov, I.V.; Borin, M.L.; Azizova, O.A.
Biulleten' Eksperimental'noi Biologii i Meditsiny 107(2): 188-190
1989
ISSN/ISBN: 0365-9615 PMID: 2538169 Document Number: 326814
The sodium-proton exchange was determined in platelets of spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). The platelets were suspended in sodium propionate; the cytoplasmic acidification activated the exchanger and intracellular pH (the increasing) and volume of the platelets (the swelling) were registered. The activity of Na+/H+ exchange was inhibited by isopropyl amiloride. The platelets' volume and the exchange rate constant of SHR were increased on 30-40% as compared with those of WKY.