Top Abstract Purchase Related
Home
>
Node
>
Subnode

Cosegregation studies in spontaneously hypertensive rats

Katsuya, T.; Ogihara, T.

Nihon Rinsho. Japanese Journal of Clinical Medicine 51(6): 1602-1609

1993

ISSN/ISBN: 0047-1852
PMID: 8320840
Document Number: 410893
SHR (spontaneously hypertensive rat) is the most popular genetic hypertensive model rat. Using the F2 progeny obtained from SHR and normotensive rats, for example, WKY (Wistar-Kyoto rat), many cosegregation studies to find the genes responsible for blood pressure have been done. In this review, we present some studies using F2 rats concerning candidate genes, renin, kallikrein, sodium potassium-ATPase, heat shock protein 70, angiotensin converting enzyme, phospholipase C-delta 1 and SA gene to show whether these genes really associate with blood pressure. We discuss the signification of these genes in the process of producing SHR and stroke-prone SHR from WKY. We hope these studies will lead to identify the mechanism of human essential hypertension.

Document emailed within 1 workday
Secure & encrypted payments

Holcslaw, T.L.; Nichols, G.; Wilson, C. 1985: Studies on uptake and catabolism of vascular histamine in spontaneously hypertensive rats Journal of Pharmacology and Experimental Therapeutics 233(2): 352-360
Mimura, Y.; Ogura, T.; Kataoka, H.; Oishi, T.; Asano, N.; Kishida, M.; Yamauchi, T.; Ogawa, N.; Makino, H. 1997: Alterations of renal V1 and V2 receptors in spontaneously hypertensive rats and DOCA-salt hypertensive rats using computerized quantification for macro-autoradiogram Research Communications in Molecular Pathology and Pharmacology 95(1): 43-56
Sekino, T. 1975: Scanning and transmission electron microscopic studies on the retinal vessels of spontaneously hypertensive rats (SHR) Nippon Ganka Gakkai Zasshi 79(8): 887-903
Levy, J.V. 1973: Studies on the contractile effects of prostaglandins on aortic strip preparations from spontaneously hypertensive rats Research Communications in Chemical Pathology and Pharmacology 6(2): 365-381
de Jong, W.; Provoost, A.P.; Zandberg, P. 1974: Effects of adrenalectomy and of neonatal sympathectomy in normotensive, renal hypertensive and spontaneously hypertensive rats Archives Internationales de Physiologie et de Biochimie 82(2): 324-326
Ishimitsu, T.; Ono, H.; Matsuoka, H. 2006: Hypertensive organ injuries in spontaneously hypertensive rats given N(G)-nitro-L-arginine methyl ester Nihon Rinsho. Japanese Journal of Clinical Medicine 64(Suppl 5): 278-283
Januszewicz, A.; Loń, S.; Lapiński, M.; Styś, A. 1994: Effect of endothelin-3 on blood pressure in conscious spontaneously hypertensive [SHR] and DOCA-salt hypertensive rats Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society 45(1): 105-119
Wright, G.L.; McCumbee, W.D.; Broome, T.; Eaton, S. 1986: Effect of reduced food intake on blood levels of a hypertensive factor in spontaneously hypertensive rats Journal of Hypertension. Suppl: Official Journal of the International Society of Hypertension 4(5): S145-S147
Yamori, Y.; Horie, R.; Sato, M.; Fukase, M. 1976: Studies of etiology and prophylaxis of stroke--stroke-prone spontaneously hypertensive rats Nihon Rinsho. Japanese Journal of Clinical Medicine 34(1): 25-34
Ismailov, S.I. 1982: Comparative evaluation of the effect of bradykinin and angiotensin Ii on hemodynamics in normotensive rats, spontaneously hypertensive rats and rats with renovascular hypertension Biulleten' Eksperimental'noi Biologii i Meditsiny 93(3): 57-61
Yin, X.; Zhu, Y.H.; Huang, D.K.; Xu, S.F. 1995: Different distributions of opioid receptors in spontaneously hypertensive rats and Wistar-Kyoto rats Zhongguo Yao Li Xue Bao 16(4): 341-344
Ueda, M.; Masui, M.; Kawakami, M.; Matsunaga, K.; Gemba, T.; Ninomiya, M.; Nakano, A.; Torii, M.; Adachi, I.; Ito, H. 1993: Pharmacological studies on a new dihydrothienopyridine calcium antagonist. 4th communication: prophylactic and therapeutic effects of S-(+)-methyl-4,7-dihydro-3-isobutyl-6-methyl-4-(3-nitrophenyl)thieno[2, 3- b]pyridine-5-carboxylate in stroke-prone spontaneously hypertensive rats Arzneimittel-Forschung 43(12): 1291-1303
Fuentes, J.A.; Ordaz, A. 1978: The antihypertensive effect of pargyline in spontaneously hypertensive rats Archivos de Farmacologia y Toxicologia 4(1): 82-83
Markov, K.M.; Pinelis, V.G.; Kudinov, I.V.; Borin, M.L.; Azizova, O.A. 1989: Na+/H+ metabolic activity in the thrombocytes of spontaneously hypertensive rats Biulleten' Eksperimental'noi Biologii i Meditsiny 107(2): 188-190
Barbagallo, M.; Raddino, R.; Restori, G.; Boiardi, L.; Novo, S.; Strano, A. 1990: Alterations of calcium metabolism in spontaneously hypertensive rats Cardioscience 1(2): 105-107
Herrmann, H.J.; Massow, S.; Moritz, V.; Norden, C.; Kühne, C. 1987: Peculiarities of adriamycin cardiotoxicity in spontaneously hypertensive rats (SHR) Biomedica Biochimica Acta 46(8-9): S593-S596
Stoynev, A.G.; Penev, P.D.; Ikonomov, O.C.; Usunoff, K.G. 1996: Effect of transplantation of embryonic anterior hypothalamic tissue from spontaneously hypertensive rats to normotensive Wistar rats on circadian rhythms of systolic arterial pressure and heart rate Acta Physiologica et Pharmacologica Bulgarica 22(3-4): 71-75
Dadkar, N.K.; Aroskar, V.A.; Gupte, R.D.; Dohadwalla, A.N. 1984: Central pressor activity of cimetidine in spontaneously hypertensive rats Journal of Pharmacy and Pharmacology 36(7): 488-490
Berkey, D.L.; Meeuwsen, K.W.; Barney, C.C. 1990: Measurements of core temperature in spontaneously hypertensive rats by radiotelemetry American Journal of Physiology 258(3 Pt 2): R743-R749
Kong, J.Q.; Taylor, D.A.; Fleming, W.W. 1991: Mesenteric vascular responses of young spontaneously hypertensive rats Journal of Pharmacology and Experimental Therapeutics 258(1): 13-17