Comparative study of 1-cyclohexyl-4- (1,2-diphenylethyl) -piperazine and its enantiomorphs on analgesic and othe pharmacological activities in experimental animals
Nakamura, H.; Shimizu, M.
Archives Internationales de Pharmacodynamie et de Therapie 221(1): 105-121
1976
ISSN/ISBN: 0003-9780 PMID: 962421 Document Number: 102996
The analgesic activity of (.+-.)-1-cyclohexyl-4-(1,2-diphenylethyl)-piperazine (MT-45) was comparable to that of morphine. The activity of the S(+)-isomer was 1.14-1.97 times in mice and 1.00-1.23 times in rats as potent as MT-45, and 18.3-61.6 times as potent as the R(-)-isomer, which was approximately comparable to that of Spa [1,2-diphenyl-1-dimethylaminoethane]. The hyperglyce mic and miotic activities of MT-45 and its S(+)-isomer in rabbits were negligible or very low, though they showed potent morphine-like activities. The R(-)-isomer showed no or very weak effects on those, while Spa showed definite effects. The modes of action of MT-45 and its enantiomorphs are partly different from those of morphine and Spa. MT-45 belongs to a new series of compounds having a potent analgesic activity.