Hepatic zonal degeneration and necrosis in Reye syndrome
Brown, R.E.; Ishak, K.G.
Archives of Pathology and Laboratory Medicine 100(3): 123-126
1976
ISSN/ISBN: 0003-9985 PMID: 803201 Document Number: 102995
Seven pediatric cases with hepatic peripheral zonal degeneration or necrosis in the liver, or both, were studied. From the standpoint of clinicopathological features, these cases fit best into the spectrum of Reye syndrome. Exogenous toxins, such as phosphorus and drugs, could not be implicated as principal causative factors in any of the cases. In the context of Reye syndrome, fatty acids would seem to have been the toxins most likely responsible for the pathogenesis of the peripheral zonal degeneration and necrosis in the liver.