Inhibitor participation in the regulation of serum RNAse activity in the formation of immunity against influenza
Parfenova, M.S.; Maksimovich, M.B.; Bukovetskiĭ, S.I.; Tishechkina, V.A.; Lisovaia, S.P.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 6: 37-41
1976
ISSN/ISBN: 0372-9311 PMID: 948958 Document Number: 99322
It was shown that parenteral administration of lead ions caused in the blood serum of albino mice a significant decrease in the amount of the bound RNA-ase 1 inhibitor and a simultaneous increase in the activity of this enzyme. Consequently, this inhibitor served as a regulator of the serum RNA-ase 1 activity. A considerable increase in the amount of the bound and free RNA-ase 1 inhibitor was noted in the serum in the process of triple immunization of persons with live influenza vaccine; this was accompanied by a significant reduction of the free RNA-ase 1 activity. This indicated that along with other mechanisms the inhibitor apparently participated in the processes of formation of immunity against influenza.