Effects of a high fructose diet on lipogenic enzyme activities in some organs of rats fed ad libitum
Sugawa-Katayama, Y.; Morita, N.
Journal of Nutrition 105(11): 1377-1383
1975
ISSN/ISBN: 0022-3166 PMID: 1185282 Document Number: 96113
Male and female rats in 3 groups were fed on a high-carbohydrate diet freely for 4 days: group 1 was then fed on a high-maize starch diet, group 2 on a high-fructose diet without starvation and group 3 on a high-fructose diet after 2 days of starvation. The activities of lipogenic enzymes, glucose-6-phosphate dehydrogenase and malic enzyme, were estimated in liver, adipose tissue and small intestine. On day 4, the liver lipid content of group 1 was about 45, that of group 2 about 70 and that of group 3 about 115 (female) and 145 (male) mg/g wet weight. Groups 2 and 3 showed significantly higher activity of hepatic malic enzyme than group 1. The activity of intestinal malic enzyme was highest in group 1 and not significantly different between groups 2 and 3. The malic enzyme activity in adipose tissue of females of group 3 was higher than that in either sex of the other groups.