Effects of bamboo charcoal powder on lipid metabolism in hyperlipidaemic rats fed high fat diet
Yan, J.; Yue, Q.; Jia, Z.; Chen, J.; Zhang, L.
Wei Sheng Yan Jiu 45(4): 631-636
2016
ISSN/ISBN: 1000-8020 PMID: 29903335 Document Number: 689871
To evaluate of bamboo charcoal powder( BCP) on the lipid profile and mechanism in hyperlipidaemia model rats. 40 male Sprague-Dawley( SD) animals of 4 weeks old were randomly assigned into five groups: the control group fed with low-fat diet; the model control group and the test group( 2. 81, 5. 62, 11. 24 g /kg). Each group gived BCP or distilled water correspondingly, the total administration duration was 90 consecutive days. After the blood samples were collected, liver, kidneys, and white adipose around bilateral epididymis and kidneys were excised and weighed. Serum biomarkers of liver and kidney function were detected. The activities of TC, TGand MDA, T-AOC, CAT, SOD of liver were determined by corresponding test kits according to the manufacturer's protocols. Livers were also further detected by macroscopic and microscopic examinations. After 90 days of treatment, the weight of rats more than 4 weeks, liver weight and percentage of body fat, serum AST, TG and VLDL, hepatic MDA, TG, TC and liver steatosis in the model control group was all increased compared with the negative control group, indicating that the model has been successfully built. It showed that the weight of rats, liver weight and white adipose weight, serum AST, TG and VLDL, hepatic MDA, TC and liver steatosis in the three dose group was all decreased. The hepatic SOD, CAT, T-AOC in the three dose groups were all increased. The BCP could reduce the accumulation of body fat, inmprove blood lipid and hepatic steatosis in hyperlipidemia model rats.