Venezuelan equine encephalomyelitis viral infection of newly hatched chickens and embryonating eggs
Dickerman, R.W.; Bonacorsa, C.M.
American Journal of Veterinary Research 36(8): 1231-1233
1975
ISSN/ISBN: 0002-9645 PMID: 1155839 Document Number: 95124
Fewer than 25% of 12-hour-old chicks died after s/c inoculation of 5 strains or intracranial inoculation of 3 strains of Venezuelan equine encephalomyelitis virus. Mortality of embryonating chicken eggs inoculated by the allantoic route decreased from approximately 75% to 35% between 9 and 18 days of incubation, althougn all 18-day-old embryos died after intraembryonic inoculation. Thus, neither newly hatched chicks nor chick embryos (unless inoculated intraembryonically) would be of value in safety testing inactivated Venezuelan equine encephalomyelitis viral vaccines.