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Demonstration of a tumor-associated surface antigen in Marek's disease

Witter, R.L.; Stephens, E.A.; Sharma, J.M.; Nazerian, K.

Journal of Immunology 115(1): 177-183

1975

ISSN/ISBN: 0022-1767
PMID: 50345
Document Number: 94216
Surface antigenic markers were detected on three classes of Marek's disease (MD) tumour cells (MD lymphoma cells, cultured cells of the MSB-1 lymphoblastoid cell line, and JMV lymphoblastic leucaemia cells), by indirect membrane immunofluorescent staining with serum from chickens immunized with JMV cells or from rabbits immunized with MSB-1 cells. This surface antigen was not detected on normal chicken lymphocytes, RPL-16 tumour cells (transformed by an avian RNA virus, or MD virus-infected fibroblasts that were positive for viral membrane antigen (MA). Furthermore, the surface antigen appeared unrelated to embryonic or histocompatibility antigens. This antigen is provisionally designated as a Marek's disease tumour-associated surface antigen (MATSA). The MATSA's on JMV, MSB-1 and MD lymphoma cells were related but not identical as demonstrated by antiserum titration, absorption and blocking tests with homologous and heterologous systems.

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