Demonstration by immunofluorescence and immunoperoxidase of an antigen of the measles type in the osteoclasts of Paget's disease of bone
Basle, M.; Rebel, A.; Pouplard, A.; Kouyoumdjian, S.; Filmon, R.; Loepatezour, A.
Bulletin de l'Association des Anatomistes 63(182): 263-272
1979
ISSN/ISBN: 0376-6160 PMID: 233348 Document Number: 141627
The intra nuclear and intra cytoplasmic inclusions described in osteoclasts in PAGET's bone disease are morphologically similar to those observed in subacute sclerosing panencephalitis. Immunological techniques using different specific immune sera demonstrate the presence of an antigenic structure of viral origin in osteoclasts in PAGET's bone disease. A measles or a measles like virus is most likely to be involved and may play a role in the etiology of the disease.