Sesquiterpene lactones XVII. Cytostatic and pharmacological activity
Hladoń, B.; Chodera, A.
Archivum Immunologiae et Therapiae Experimentalis 23(6): 857-865
1975
ISSN/ISBN: 0004-069X PMID: 1220638 Document Number: 93856
Of four lactones studied in the systems Sa-180, EAC and L-1210, two compounds: alatolide, (ALA) and eupatoriopicrin (EUPP), according to the criteria of CCNSC, showed high cytostatic activity, and ursiniolide A (URSA) "moderate" cytostatic activity against at least one type of transplantable tumor. Two compounds were selected for further confirmatory investigation: EUPP, which gave 92% inhibition of EAC and 60% increase in survival of animals bearing Leukemia L-1210; and ALA, which gave 96% inhibition of growth of EAC.