Influence of nicotinic acid on the methylation of phospholipids in various tissues of rats
Vasyl'év, O.M.; Kucherenko, M.E.
Ukrains'kyi Biokhimichnyi Zhurnal 47(1): 82-84
1975
ISSN/ISBN: 0041-610X PMID: 1202698 Document Number: 93413
The content and methylation of total phospholipids in the brain, liver and muscles and some of their fractions obtained by the method of thin-layer chromatography on silicic acid were studied as affected by nicotinic acid. It is established that nicotinic acid in a dose of 20 mg/kg 4 hrs after subcutaneous injection evokes an increase in the content of phosphatidyl ethanol amine in the liver and sphyngomyelin in the muscles. The intensity of methylation of choline-containing phospholipids under the effect of nicotinic acid lowers in all the tissues under study.