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The influence of alpha-zearalenol on magnesium concentration in cellular subfractions of certain tissues of female rats and their progeny

Pasternak, K.; Kiełczykowska, M.łg.; Sztanke, M.łg.; Borzecki, A.

Magnesium Research 16(2): 106-110

2003

ISSN/ISBN: 0953-1424
PMID: 12892380
Document Number: 555851
The purpose of the research work was to study the influence of alpha-zearalenol on magnesium concentration in cellular subfractions of certain tissues of female rats and their progeny. Pregnant female rats received alpha-zearalenol at the doses of: 0.05, 0.5 or 1 mg x kg(-1) b.w. After delivery, brain, liver and kidneys of female rats and their progeny were removed and magnesium concentration was measured in cellular subfractions of these tissues. Alpha-zearalenol reduced Mg-level in all the cellular subfractions of female rat tissues. In progeny tissues, alpha-zearalenol decreased magnesium concentration in nuclear subfraction only. In mitochondrial and cytosol subfractions it increased Mg-concentration. The changes in magnesium concentration were depended on alpha-zearalenol doses and tissue nature. The magnesium concentration decrease was higher in female rats than in progeny tissues.

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