Cytogenetic characteristics of the growth of mouse ascitic strain L-5178
Fomina, M.M.; Minenkova, E.A.; Poroshenko, G.G.; Evseenko, L.S.
Tsitologiia 17(2): 188-194
1975
ISSN/ISBN: 0041-3771 PMID: 1056646 Document Number: 93249
The number of chromosomes in the cells of L-5178 ascites tumor vary from 38 to 46. The modal class consists of two cell lines with 43 and 44 chromosomes. The number of polyploid cells changes in the process of tumor growth from 11% within first 10 days after transplantation to 50% on the 21st-22en days. The tumor cell population manifests a number of metaphases with endoreduplication of chromosomes. The per cent of metaphases with diplochromosomes varies from 0.05% on the 7th day of tumor development to 5.0% on the 15th-17th day. L-5178 tumor cells are characterized by the presence of structurally changed chromosomes: the acrocentric chromosome with the secondary constriction, metacentric, and 2-3 small chromosomes.