Polymorphism of a tumor cell population and selective processes. III. a change in the correlation of tumor cell subpopulations of the ascitic strain of Ehrlich-I.Ch.Ph. under the influence of glucose and sodium succinate
Fomina, M.M.; Minenkova, E.A.; Lankin, V.Z.; Poroshenko, G.G.; Evseenko, L.S.
Tsitologiia 21(8): 953-958
1979
ISSN/ISBN: 0041-3771 PMID: 291223 Document Number: 152174
A study was made of the action of glucose or sodium succinate on subpopulations of the Ehrlich-I.Ch.Ph. ascite strain characterised by markers "A1" and "A", resp. After i.p. injection of glucose the amount of "A1"-cell reached 50 and almost 100% on the 5th and 7th day of tumor growth. After the transplantation of "A1"-cells into intact animals, a homogenous cytogenetic feature of subpopulation persisted during 2 passages only. Kinetics studies of a subvariance of the Ehrlich-I.Ch.Ph. tumor containing "A1"-cells show that the tumor growth rate and grade of malignancy slightly differ from those seen in the controls.