Top Abstract Purchase Related
Home
>
Node
>
Subnode

Study of mechanisms of regulation of disulphide reductase in mouse liver

Kulinsky, V.I.; Kolesnichenko, L.S.

Voprosy Meditsinskoi Khimii 21(3): 286-290

1975

ISSN/ISBN: 0042-8809
PMID: 174302
Document Number: 93095
An increase in activity of disulphide reductase system (DRS) in supernatant of liver tissue was caused by 3',5'-AMP, ATP, GTP, UTP, Mg2+, Ca2+, EDTA, protamine, noradrenaline and F-. The effect was connected with arsenite resistant fraction of DRS. After rapid homogenization the effect of noradrenaline disappeared and the effects of ATP, GTP, UTP and Ca2+ were distinctly decreased. Treatment with adsorbents prevented the effects of 3',5,-AMP, ATP and EDTA and markedly decreased the effects of protamine and Mg2+. A protein inhibitor of protein kinase prevented completely the activation of DRS with 3',5'-AMP, ATP, GTP, UTP and noradrenaline and distinctly decreased the effect of protamine, Mg2+ and Ca2+ but did not alter the influence of EDTA. Addition of 2',3'-AMP blocked the effect of 3',5-AMP, ATP and Mg2+ but did not influence the effect of protamine and EDTA. The data obtained suggest that protein kinase participated in activation of DRS by most of the regulators.

Document emailed within 1 workday
Secure & encrypted payments

Hayes, J.D.; McLeod, R.; Ellis, E.M.; Pulford, D.J.; Ireland, L.S.; McLellan, L.I.; Judah, D.J.; Manson, M.M.; Neal, G.E. 1996: Regulation of glutathione S-transferases and aldehyde reductase by chemoprotectors: studies of mechanisms responsible for inducible resistance to aflatoxin B1 Iarc Scientific Publications 139: 175-187
Anderson, S.J.; Coleclough, C. 1993: Regulation of CD4 and CD8 expression on mouse T cells. Active removal from the cell surface by two mechanisms Journal of Immunology 151(10): 5123-5134
Choy, B.K.; McClarty, G.A.; Chan, A.K.; Thelander, L.; Wright, J.A. 1988: Molecular mechanisms of drug resistance involving ribonucleotide reductase: hydroxyurea resistance in a series of clonally related mouse cell lines selected in the presence of increasing drug concentrations Cancer Research 48(8): 2029-2035
Kuljak, S.; Stern, P. 1971: Protective effects of glutathione and xanthinol nicotinate against carbon disulphide poisoning in the mouse Arhiv Za Higijenu Rada i Toksikologiju 22(2): 137-142
Khlebodarova, T.M.; Serov, O.L.; Korochkin, L.I. 1978: Gene regulation of the lactate dehydrogenase isoenzyme spectrum in the mouse liver Genetika 14(7): 1213-1220
Morello, D.; Lavenu, A.; Babinet, C. 1990: Differential regulation and expression of jun, c-fos and c-myc proto-oncogenes during mouse liver regeneration and after inhibition of protein synthesis Oncogene 5(10): 1511-1519
Luck, D.N.; Gout, P.W.; Sutherland, E.R.; Fox, K.; Huyer, M.; Smith, M. 1992: Analysis of disulphide bridge function in recombinant bovine prolactin using site-specific mutagenesis and renaturation under mild alkaline conditions: a crucial role for the central disulphide bridge in the mitogenic activity of the hormone Protein Engineering 5(6): 559-567
Bartholomaeus, W.N.; Reed, W.D.; Joske, R.A. 1984: Autoantibody to liver-specific lipoprotein in the mouse: regulation by naturally occurring autoantigen specific suppressor cells Clinical and Experimental Immunology 58(2): 307-316
Cecha, J.ós.; Drabek, G.; Błazelonis, A.; Romanowski, W.; Zubelewicz-Szkodzińska, B. 2004: The role of HMG-CoA reductase inhibitors in regulation of the inflammatory processes Wiadomosci Lekarskie 57(5-6): 255-258
Yamauchi, K.; Yamamoto, T.; Hayashi, H.; Koya, S.; Takikawa, H.; Toyoshima, K.; Horiuchi, R. 1987: Sequence of membrane-associated thyroid hormone binding protein from bovine liver: its identity with protein disulphide isomerase Biochemical and Biophysical Research Communications 146(3): 1485-1492
Ozaki, S. 1974: Effect of lipids on liver microsomal membranes. (1) Studies of a relationship between delipidation of liver microsomes with the various organic solvents and cytochrome c reductase activity linked to reduced nicotinamide adenine dinucleotide Hokkaido Journal of Medical Science 49(4): 326-336
Sroka, J.; Madeja, Z. 2009: Reactive oxygen species in regulation of cell migration. the role of thioredoxin reductase Postepy Biochemii 55(2): 145-152
Avtandilov, G.G.; Sirotkin, V.V.; Kozyreva, E.V. 1981: Morphofunctional characteristics of mouse liver mitochondria (morphologic and biochemical study) Biulleten' Eksperimental'noi Biologii i Meditsiny 92(8): 96-97
Mishin, V.M.; Guliaeva, L.F.; Mishina, D.V.; Gutkina, N.I. 1984: Immunological study of the identity of cytochrome P-448 in the mouse and rat liver after induction with 3-methylcholanthrene Voprosy Meditsinskoi Khimii 30(5): 98-102
Ricordi, C.; Zeng, Y.; Carroll, P.B.; Rilo, H.L.; Beretier, D.R.; Starzl, T.E.; Ildstad, S.T. 1992: Islet xenografts in fully xenogeneic (rat----mouse) chimeras: evidence for normal regulation of function in a xenogeneic mouse environment Surgery 112(2): 327-332
Philips, F.S.; Sirotnak, F.M.; Sodergren, J.E.; Hutchison, D.J. 1973: Uptake of methotrexate, aminopterin, and methasquin and inhibition of dihydrofolate reductase and of DNA synthesis in mouse small intestine Cancer Research 33(1): 153-158
Margolis, S.; Philips, F.S.; Sternberg, S.S. 1971: The cytotoxicity of methotrexate in mouse small intestine in relation to inhibition of folic acid reductase and of DNA synthesis Cancer Research 31(12): 2037-2046
Ducouret, B.; Samperez, S.; Jouan, P. 1978: Hormonal regulation of 5 alpha-reductase activity in anterior pituitary gland microsomes of the male rat Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 172(6): 1201-1207
Yi, J.-h.; Liu, Z.-l.; Li, G.-x.; Wang, R.; Wang, X.-y.; Qiu, L.-m.; Wu, T.-c. 2004: Experimental study on carbon disulphide-induced vascular endothelial damage and the intervention of vitamin C Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 22(3): 215-216
Valantine, H.A.; Schroeder, J.S. 1997: HMG-CoA reductase inhibitors reduce transplant coronary artery disease and mortality: evidence for antigen-independent mechanisms? Circulation 96(5): 1370-1373