The role of HMG-CoA reductase inhibitors in regulation of the inflammatory processes
Cecha, J.ós.; Drabek, G.; Błazelonis, A.; Romanowski, W.; Zubelewicz-Szkodzińska, B.
Wiadomosci Lekarskie 57(5-6): 255-258
2004
ISSN/ISBN: 0043-5147 PMID: 15518071 Document Number: 571731
Statins operate through inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, a key enzyme which regulates intracellular cholesterol synthesis. Their so-called pleiotropic effects incorporate alterations of endothelial function, inflammation, coagulation and plaque stability. This review will focus on statins regulation role in inflammation.