Splenectomy by ethylpalmitate in Wistar rats
Jirásek, A.; Sebestik, V.
Ceskoslovenska Patologie 11(3): 147-152
1975
ISSN/ISBN: 1210-7875 PMID: 1239335 Document Number: 91119
Necrosis of the spleen resulting from previous storage of the substance within the cells was produced by intravenous injections of 500 mg and 800 mg, respectively, of ethylpalmitate in 30 male Wistar [VELAZ] rats weighting, on average, 200 g. A certain inhomogeneity of the results indicates differences in tissue susceptibility obviously related to the actual functinal state at the spleen. Ethylpalmitate storage was observed to a lesser degree in the Kupffer cells of the liver and in the cells of pulmonary alveoli and septa. This, however, was unassociated with marked necrosis. Other organs [lymph nodes, bone marrow, thymus, kidney, myocardium] did not display significant changes.