Biochemical changes in 24-month-old Wistar rats
Roman, F.; Della Zuana, O.; Lonchampt, M.; Saint Romas, G.; Duhault, J.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 178(4): 372-381
1984
ISSN/ISBN: 0037-9026 PMID: 6084545 Document Number: 238642
Biogenic amines in pons and striatum have been dosed in twenty-four months old Wistar male rats. Choline acetyltransferase (CAT) and acetylcholine esterase (ACHesterase) activities, [3H] choline uptake by a synaptosomal preparation, [3H] quinuclidinyl benzylate (QNB) binding to muscarinic cholinergic receptors have been determined in hippocampus. Malondialdehyde (MDA) levels in plasma, in liver and in lungs and the characteristics of the skin collagen have been evaluated. Important differences are shown in comparison with three months old of the same strain animals.