N-Phthaloyl gamma-aminobutyric acid affects biochemical circadian rhythms in Wistar rats
Subramanian, P.; Sundaresan, S.; Balamurugan, E.
Indian Journal of Experimental Biology 39(4): 360-364
2001
ISSN/ISBN: 0019-5189 PMID: 11491582 Document Number: 539936
N-Phthaloyl gamma-aminobutyric acid (P-GABA) was administered to Wistar rats and 24 hr rhythms of glucose, cholesterol, total protein and lactic acid levels in blood were studied under semi-natural light dark conditions. P-GABA administration caused desynchronisation of the rhythms; while glucose and lactic acid rhythms were advanced, cholesterol and total protein rhythms were delayed. Since GABA is being involved in conveying dark information to the clock, exogenous administration of P-GABA may reduce the photic information received by the clock. The results could be explained by slightly less than 1 hr daily delays (or) advances respectively which would bring the peak times to the points 21 days after the start of administration.