A method for the study of relations between the lung and the reticulo-endothelial system
Grunspan, M.
Pathologie-Biologie 23(6): 470-474
1975
ISSN/ISBN: 0369-8114 PMID: 53806 Document Number: 91064
The experiments reported in this paper draw attention to three new facts : 1) the reticulo-endothelial system (RES) of normal Rat can be " filled " with a non toxic, polymeric substance, PVNO, which is taken up by macrophages by pinocytosis ; 2) a broncho-pulmonary irritation leads to a discharge of PVNO by the macrophage. The macrophages are poured out into the blood stream, whence they arrive in to the lung ; 3) this discharge of a polymer as PVNO which has been previously taken in the macrophage, can happen even 10-12 months after the filling of the RES by the macromolecule.