GABA-ergic mechanisms of the action of ketamine on the structures of the hippocampo-reticulo-neocortical system of the brain
Krauz, V.A.; Mamchur, V.I.
Farmakologiia i Toksikologiia 51(1): 29-31
1988
ISSN/ISBN: 0014-8318 PMID: 2834220 Document Number: 315664
In freely mobile rabbits with electrodes preliminarily implanted in the brain structures ketamine (5 mg/kg intravenously or 20 mg/kg intramuscularly) exhibited properties of GABA receptor agonist decreasing the direct excitability of the mesencephalic reticular formation and periaqueductal gray matter and reducing their activating effect on the frontal cortex (FC) and dorsal region of the hippocamp (DH). GABA-mimetics (muscimol, baclofen, aminooxyacetic acid) as well as GABA system antagonists (bicuculline, thiosemicarbazide) attenuated ketamine action at the level of DH and especially FC.