Fenibut and fenazepam as potential protectors of pregnancy with a GABA-ergic mechanism of action
Sergeev, P.V.; Sizov, P.I.; Dukhanin, A.S.
Eksperimental'naia i Klinicheskaia Farmakologiia 60(2): 33-36
1997
ISSN/ISBN: 0869-2092 PMID: 9206566 Document Number: 483954
It has been shown that the GABAergic system of the myometrium takes part in regulation of uterine contractility during the development of pregnancy Fenibut and phenazepam exhibit a specific uterotropic effect. The uterodepressant effect of fenibut is realized via the inhibiting GABA-receptors of the myometrium. The uteroinhibiting effect of phenazepam is mediated through the interaction with the postsynaptic GABA-benzodiazepin-C1-receptor complex of the myometrium.