Hemodynamic mechanism of the hypotensive action of beta-phenyl-GABA esters (phenibut)
Tiurenkov, I.N.
Farmakologiia i Toksikologiia 46(1): 54-59
1983
ISSN/ISBN: 0014-8318 PMID: 6825820 Document Number: 219479
It was established in acute and chronic experiments on cats that phenibut ethers are 7-10 times more potent than phenibut itself as regards hypotensive activity and produce inconsistent effects on the cardio- and hemodynamics. Of these ethers, methyl ether of phenibut is the most powerful agent. It causes lasting hypotension when given in doses of 1/50 and 1/30 of the LD50 at the cost of a decrease in the general peripheral resistance. At the same time, apart from raising the blood inflow to the heart and cardiac output, the drug has a compensated adverse ino- and chronotropic action on the heart.