GABA-ergic system in defense against excitatory kynurenines
Lapin, I.P.
Voprosy Meditsinskoi Khimii 43(6): 548-552
1997
ISSN/ISBN: 0042-8809 PMID: 9503572 Document Number: 470144
Protection against the excitatory action of L-kynurenine and quinolinic acid in mice is related to the activation of GABA-B and dopamine receptors of the brain and to much lesser degree to the activation of GABA-A receptors. It is hardly believable that the anticonvulsant effect of phenibut (beta-phenyl-GABA), baclofen (CL-phenibut), sodium hydroxybutyrate and taurine against seizures induced by these two kynurenines is determined by alterations in metabolism of GABA.