Peroxidase activity in the paw of animals in adjuvant arthritis and its changes by antiphlogistics in vitro
Bekemeier, V.H.; Hirschmann, R.; Giessler, A.J.
Zeitschrift für Rheumatologie 34(3-4): 71-75
1975
ISSN/ISBN: 0340-1855 PMID: 1136598 Document Number: 88655
The peroxidase activity is increased in the inflamed paw of rats with adjuvant arthritis. The increase is biphasic like for other enzymes. The higher peak occurs during primary inflammation in the injected paw according to the behaviour of polymorphonuclear leucocytes. Of 32 substances tested in vitro, among them 19 antiphlogistics and derivatives, especially the antiphlogistics inhibited the peroxidase reaction. Therfore it seems not unlikely that inhibition of the peroxidase reaction is involved in the mechanism of activity of anti-inflammatory agents.