Combination of cyclosporine a and calcitriol in the treatment of adjuvant arthritis
Boissier, M.C.; Chiocchia, G.; Fournier, C.
Journal of Rheumatology 19(5): 754-757
1992
ISSN/ISBN: 0315-162X PMID: 1613705 Document Number: 399121
We investigated combination treatment with cyclosporine A (CsA) and calcitriol (CT), 2 immunomodulatory agents, in vivo in the adjuvant arthritis (AA) model in rats. Treatment initiated at priming with complete Freund's adjuvant consisted of daily administration of CsA and CT during the prearthritic phase (14 days). CsA given alone delayed the onset of the disease, whereas the severity was either not affected or paradoxically enhanced. Injection of CT alone reduced the severity of arthritis. The association of low doses of CsA (5 mg/kg) and CT (0.2 micrograms/kg) further delayed the onset of AA and abolished the aggravating effect. Our findings suggest that low doses of CsA and CT in association exhibit the additive beneficial effects of either agent alone.