The efficacy of an erythropoietin-calcitriol combination in patients with chronic kidney failure on programmed hemodialysis
Nikolaev, A.Iu.; Klepikov, P.V.; Lashutin, S.V.; Kukhtevich, A.V.
Terapevticheskii Arkhiv 67(5): 27-31
1995
ISSN/ISBN: 0040-3660 PMID: 7638771 Document Number: 445638
In 8 patients with chronic renal failure (CRF) on hemodialysis combined therapy (erythropoietin+calcitriol) effect was evaluated versus control group of 9 hemodialysis patients on erythropoietin monotherapy. In patients on the combined regimen the antianemic effect occurred sooner, this effect of calcitriol coming prior to correction of uremic defects in phosphoric-calcium metabolism. Calcitriol mechanisms of action in renal anemia and benefits of potential calcitriol+erythropoietin combination use in CRF patients suffering from uremic osteodystrophy, hypercatabolic conditions, uremic hypogonadism and infection complications are discussed.