The immunohistologic features of synovitis, disease activity and in vitro IgM rheumatoid factor synthesis by blood mononuclear cells in rheumatoid arthritis
Rooney, M.; Whelan, A.; Feighery, C.; Bresnihan, B.
Journal of Rheumatology 16(4): 459-467
1989
ISSN/ISBN: 0315-162X PMID: 2746585 Document Number: 334483
The immunohistological characteristics of synovial membrane obtained form patients with active rheumatoid arthritiis (RA) were correlated with disease activity and spontaneous in vitro synthesis of IgM rheumatoid factor (RF) by peripheral blood mononuclear cell infiltration and Positive correlations were found between the intensity of inflammatory cell infiltration and both disease activity (p = 0.007) and RF synthesis (p = 0.028). Moreover, the intensity of both T cell and B cell infiltration correlated significantly with disease activity. Within the group studied 3 previously described immunohistological categories were identified. These categories could not be distinguished by clinical measurements, but did differ with respect to respect to their capacity for spontaneous in vitro IgM RF synthesis by blood MNC. Our study provides evidence that a relationship does exist between the immunohistologic characteristics and disease severity in RA. Furthermore, the concept of distinct histologic categories of RA representing different immunopathogenic mechanisms is supported.