Effect of various amino acids and their antagonists on the cholinergic tremor and acetylcholine release in the CNS of the rat
Scherber, A.; Staib, A.H.; Oelszner, W.
Acta Biologica et Medica Germanica 34(9): 1517-1524
1975
ISSN/ISBN: 0001-5318 PMID: 1221739 Document Number: 87706
Glycine and GABA administered intraventricularly and intrastriatally were found to inhibit the oxotremorin tremor in rats. The two amino acids reduce both the spontaneous release of acetylcholine into the ventricle and the discharge measured under oxotremorin treatment. The inhibition of the tremor and of acetylcholine release can be blocked by amino acid antagonists (strychnine and picrotoxin), whose effects are not specific for one of these amino acids; this action can be interpreted as effect of interference with other central transmission systems. Structures located close to the ventricles (nigrostriatal path ways) are discussed as possible points of action.