Quantitative study of the effect of previous Trichinella spiralis infection on sarcoma 180 ascitic tumor formation in mice
Lubiniecki, A.S.; Cypess, R.H.
Tropenmedizin und Parasitologie 26(3): 329-334
1975
ISSN/ISBN: 0303-4208 PMID: 1189027 Document Number: 87425
Mice infected orally with 200 Trichinella spiralis larvae were inoculated 28 or 56 days later with 5 X 102 or 5 X 104 Sarcoma 180 (S-180) cells. Those challenged after 28 days demonstrated longer incubation periods and survival than control mice, independent of S-180 dose. However the relative rates of weight gain and duration were not significantly different from those of control mice. All mice died at the higher dose. Administration of tumour cells 56 days after the helminth had no detectable effect on any parameter of tumour development studied. It is suggested that T. spiralis infection temporarily altered the host reaction to S-180, possibly at the level of non-specific macrophage activity.