Hemostasis suppression by a combination of heparin and acetylsalicylic acid
Wamhoff, D.; Schmechel, H.
Zeitschrift für die Gesamte Innere Medizin und ihre Grenzgebiete 30(18): 178-180
1975
ISSN/ISBN: 0044-2542 PMID: 1216936 Document Number: 86956
The effect of a combined application of acetylsalicylic acid and heparin on haemostasis is examined on 7 healthy test persons. Apart from the change of the plasmatic coagulation and the platelet function by the pharmaca a prolongation of the bleeding time which is larger than the values of the individual application can be established. In the in-vitro-experiment could be proved that the prolonged bleeding time is based on the prevented by acetylsalicylic acid release of the heparin neutralising factor 4 from the platelets. An improvement of the therapeutic effect of heparin when at the same time acetylsalicylic acid is given is discussed.