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Activation of the alternative (properdin) pathway by divalent cations

Lew, F.T.; Yukiyama, Y.; Waks, H.S.; Osler, A.G.

Journal of Immunology 115(3): 884-888

1975

ISSN/ISBN: 0022-1767
PMID: 807649
Document Number: 85747
Mg++, Mn++ and Co++ activate the C system as judged by the reduction in cobra venom factor indeed hemolysis, and cleavage of properdin factor B and C3. The maximum effect requires the addition of 5 to 10 mM of these cations to dialyzed sera respond in similar fashion indicating that these divalent cations can trigger the alternative pathway without the addition other activating agents.

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