Effect of the mitochondrial ionophore for divalent cations on bilayer phospholipid membranes
Makhmudova, E.M.; Gagel'gans, A.I.; Mirkhodzhaev, U.Z.; Tashmukhamedov, B.A.
Biofizika 20(2): 225-227
1975
ISSN/ISBN: 0006-3029 PMID: 1170900 Document Number: 95325
It has been shown that ionophore of bivalent cations (IBC) isolated from fatless, subjected to partial triptic hydrolysis cattle heart or liver mitochondria decreases BPM resistance inducing Ca2+ conductivity. Ions of lanthane in micromolar concentrations decrease calcium conductivity induced with IBC. When ten-fold gradient in Ca2+ was created on BPM the intitiation of the membrane potential fo 9-11 mV was observed. The role fo IBC and water soluble factors binding Ca2+ with high affinity, in the mitochrondial mechanism of Ca2+ translocation is discussed.