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Histological findings of hypersplenism after experimental intraperitoneal injection of methyl cellulose and ligature of the splenic artery in rats

Domres, B.; Gruenagel, H.H.; Zittel, R.X.

Acta Hepato-Gastroenterologica 22(4): 215-221

1975

ISSN/ISBN: 0300-970X
PMID: 1179943
Document Number: 85339
The intraperitoneal injection of methyl cellulose in rats causes splenomegaly and hypersplenism. Clusters of foam cells in form of granulomas develop. They are containing methyl cellulose. The ligature of the splenic artery damages mainly the white pulp. Even after ligature of the splenic artery absorption of methyl cellulose continues. The reticular cells released by the reticulum remain capable of phagocytic action. After previous injection of methyl cellulose the ligature of the splenic artery causes normalization of the peripheral blood values.

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Histological findings of hypersplenism after experimental intraperitoneal injection of methyl cellulose and ligature of the splenic artery in rats

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