A long-term investigation of transcatheter splenic arterial embolization for hypersplenism
Sakata, K.; Hirai, K.; Tanikawa, K.
Hepato-Gastroenterology 43(7): 309-318
1996
ISSN/ISBN: 0172-6390 PMID: 8682485 Document Number: 796
Background/Aims: This study investigated long-term changes in the parameters of blood and liver function tests following TSAE. Patients and Materials: Twenty-five patients received transcatheter splenic arterial embolization (TSAE) as a treatment for hypersplenism, and their post-TSAE conditions were monitored for over a year. We evaluated changes in blood and liver function tests, and examined changes of platelet associated immunoglobulin G (PA-IgG), liver and spleen volumes and hemodynamics in order to consider the mechanism of liver function improvement following TSAE. Results: In blood tests, platelet and WBC counts significantly increased one year after TSAE and this increased level continued up to the fifth year. In liver function tests, levels of serum total protein, albumin, total cholesterol, and results of the hepaplastin test significantly improved after the one year, and these levels remained even over one year. Conclusions: Results of this study indicated involvements of decreased platelet pool in the spleen and probable immunological mechanisms in association with PA-IgG in platelet count increase. Indocyanine green clearance (15') were improved in 5 of 8 patients (62.5%) after TSAE. These points may indicate an involvement of hemodynamic changes in the improvement of liver function parameters.
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