Histological changes in the vas deferens of rats after injection of a new male antifertility agent "SMA" and its reversibility
Sethi, N.; Srivastava, R.K.; Singh, R.K.
Contraception 41(3): 333-339
1990
ISSN/ISBN: 0010-7824 PMID: 2323221 DOI: 10.1016/0010-7824(90)90074-6Document Number: 503907
A new male antifertility agent, styrene maleic anhydride (SMA) dissolved in dimethyl sulphoxide (DMSO), was injected into the vas deferens of rats. The morphological changes detected were confined only to the mucosa. After four weeks, the vas deferens lumen was flushed with the solvent DMSO, and the mucosal structures returned to normal.
Document emailed within 0-6 h
Related Documents
Zhou, Z.-y.; Hu, L.-q.; Wang, H.-p.; Li, S.-w.; Ma, S.-l.; Tang, Q. 2006: Antifertility effect of 30% ethanol retro-injection into rat vas deferens Zhonghua Nan Ke Xue 12(7): 602-604Zhao, S.C. 1990: Vas deferens occlusion by percutaneous injection of polyurethane elastomer plugs: clinical experience and reversibility Contraception 41(5): 453-459
Setty, B.S.; Kar, A.B. 1970: Nature and site of action of 3-chloro-1,2-propanediol--an oral antifertility agent for the male Indian Journal of Experimental Biology 8(1): 49-50
Lu, R.F.; Zou, G. 1979: Experimental pharmacologic studies on the male antifertility agent alpha-chlorohydrin and its analogues Yao Xue Xue Bao 14(7): 402-407
Freeman, C.; Coffey, D.S. 1973: Male sterility induced by ethanol injection into the vas deferens International Journal of Fertility 18(3): 129-132
Zhang, X.G.; Xu, Y.; Qian, S.Z. 1987: Injection of copper powder into epididymides via vas deferens on male fertility Advances in Contraceptive Delivery Systems: Cds 3(2-3): 167-171
Waghmare, A.; Kanyalkar, M.; Joshi, M.; Srivastava, S. 2011: In-vitro metabolic inhibition and antifertility effect facilitated by membrane alteration: search for novel antifertility agent using nifedipine analogues European Journal of Medicinal Chemistry 46(9): 3581-3589
Singh, A.K. 2002: Intra-vas deferens injection of styrene maleic anhydride gel for male contraception: is it safe? Journal of Family Planning and Reproductive Health Care 28(4): 208-209
Debeljuk, L.; Schally, A.V. 1986: Antifertility effects of a potent LH-RH antagonist in male and female rats International Journal of Fertility 31(4): 284-292
Choudhary, D.N.; Singh, J.N.; Verma, S.K.; Singh, B.P. 1990: Antifertility effects of leaf extracts of some plants in male rats Indian Journal of Experimental Biology 28(8): 714-716
Schoutens, A.; Verhas, M.; L'Hermite-Baleriaux, M.; L'Hermite, M.; Verschaeren, A.; Dourov, N.; Mone, M.; Heilporn, A.; Tricot, A. 1984: Growth and bone haemodynamic responses to castration in male rats. Reversibility by testosterone Acta Endocrinologica 107(3): 428-432
Koul, V.; Srivastav, A.; Guha, S.K. 1998: Reversibility with sodium bicarbonate of styrene maleic anhydride, an intravasal injectable contraceptive, in male rats Contraception 58(4): 227-231
Kalla, N.R.; Gadru, N.; Foo, T.W. 1986: Studies on the male antifertility agent gossypol acetic acid. VII. Effect of motility stimulated factors on the revival of human spermatozoal motility after gossypol treatment in vitro Andrologia 18(4): 393-397
Misro, M.M.; Chaki, S.P.; Kaushik, M.C.; Nandan, D. 2009: Trials for development of once-a-month injectable, hormonal male contraceptive using dienogest plus testosterone undecanoate: dose standardization, efficacy and reversibility studies in rats Contraception 79(6): 488-497
Kalla, N.R.; Vasudev, M. 1981: Studies on the male antifertility agent-gossypol acetic acid. II. Effect of gossypol acetic acid on the motility and ATPase activity of human spermatozoa Andrologia 13(2): 95-98
Domres, B.; Gruenagel, H.H.; Zittel, R.X. 1975: Histological findings of hypersplenism after experimental intraperitoneal injection of methyl cellulose and ligature of the splenic artery in rats Acta Hepato-Gastroenterologica 22(4): 215-221
Qian, S.Z.; Wang, Z.G. 1984: Gossypol: a potential antifertility agent for males Annual Review of Pharmacology and Toxicology 24: 329-360
Gargiulo, P.A.; Donoso, A.O. 1996: Distinct grooming patterns induced by intracerebroventricular injection of CRH, TRH and LHRH in male rats Brazilian Journal of Medical and Biological Research 29(3): 375-379
Zivna, H.; Zivny, P.; Palicka, V.; Nozicka, J. 2001: The differences in selected biochemical markers and histological findings after bile duct ligation in male and female rats Advances in Clinical Pathology: the Official Journal of Adriatic Society of Pathology 5(4): 147-153
Xue, S. 2000: A beam of dawn light of study on gossypol as a safe, effective, and reversible male antifertility contraceptive--evaluation of the studies by using low dose gossypol combined with steroid hormone for male contraception Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae 22(3): 211-213