Rate of disappearance of cholinesterase inhibitors from the circulating blood as dependent on their chemical structure
Turov, M.I.; Smusin, I.S.; Babakhanian, R.V.
Zhurnal Eksperimental'noi i Klinicheskoi Meditsiny 15(2): 21-24
1975
ISSN/ISBN: 0514-7484 PMID: 1136636 Document Number: 85311
In cats a study of the rate of passage from circulating blood into other tissues of neostigmine, physostigmine and 2 series of organophosphorus compounds, i.e., methylthiophosphonates and their corresponding methylsulfomethylates with a different length of the alkoxyl radical (methyl, butyl, octyl), established that the rate of passage increases considerably under the effect of a constant positive charge in the molecule of the substance and also depends on the hydrophobicity of the molecule of the substance. An increased rate of passage is observed when the O-methyl radical in the phosphoryl part of the molecule of the organophosphorus compound is replaced by the O-butyl radical. The rate of passage of derivatives with the O-octyl radical proved to be slightly lower than that of their analogs with the O-butyl radical.