Mechanism of the hypothermic action of reversible cholinesterase inhibitors
Tonkopiĭ, V.D.
Farmakologiia i Toksikologiia 38(2): 141-144
1975
ISSN/ISBN: 0014-8318 PMID: 1227897 Document Number: 92242
Experiments set up on mice demonstrated that galanthamine, hydrobromide, physostymine salicilate and iodomethylate produce a fall of the renal temperature, the hypothermal effect being proportional to the suppression of the cerebral cholinesterase. Anticholinergics benactyzine and atropine were largely capable of preventing hypothermia produced by the introduction of galathamine hydrobromide, the latter increasing the resistance of the animals to the action of high temperature.