Structure/activity studies of flavonoids as inhibitors of cyclic AMP phosphodiesterase and relationship to quantum chemical indices
Ferrell, J.E.; Chang Sing, P.D.; Loew, G.; King, R.; Mansour, J.M.; Mansour, T.E.
Molecular Pharmacology 16(2): 556-568
1979
ISSN/ISBN: 0026-895X PMID: 229402 Document Number: 142749
Document emailed within 1 workday
Related Documents
Singh, P.; Sharma, R.C.; Ojha, T.N. 1991: Quantitative structure-activity relationship studies of inhibitors of gastric (H+/K+)-ATPase Drug Design and Delivery 7(2): 131-138Ojha, T.N.; Singh, P.; Sharma, R.C. 1993: Structure-activity relationship studies of 4-substituted-2-guanidinothiazoles: reversible inhibitors of gastric (H+/K+)-ATPase Indian Journal of Biochemistry and Biophysics 30(4): 239-243
Ferre, F.; Germain, G.; Leroy, M.J.; Breuiller, M. 1985: Relationship between myometrial cyclic nucleotide phosphodiesterase (PDE) activity and the RNA/DNA ratio at various stages of gestation in primates Acta Physiologica Hungarica 65(4): 433-441
Agresti, A.; Buffoni, F.; Kaufman, J.J.; Petrongolo, C. 1980: Structure--activity relationships of eseroline and morphine: ab initio quantum-chemical study of the electrostatic potential and of the interaction energy with water Molecular Pharmacology 18(3): 461-467
Barnette, M.S.; Manning, C.D.; Cieslinski, L.B.; Burman, M.; Christensen, S.B.; Torphy, T.J. 1995: The ability of phosphodiesterase IV inhibitors to suppress superoxide production in guinea pig eosinophils is correlated with inhibition of phosphodiesterase IV catalytic activity Journal of Pharmacology and Experimental Therapeutics 273(2): 674-679
Sankar, D.V.; Kumbar, M. 1974: Quantum chemical studies on drug actions. IV. Correlation of substituent structures and anti-serotonin activity in lysergamide series Research Communications in Chemical Pathology and Pharmacology 7(2): 259-274
Stürzebecher, J.; Markwardt, F.; Wagner, G.; Walsmann, P. 1976: Synthetic inhibitors of serine proteinases. 13. Quantitative structure-activity relationship for inhibition of trypsin and thrombin by 4-amidinophenyl compounds with a ketone structure Acta Biologica et Medica Germanica 35(12): 1665-1676
Gräfe, U.; Römer, W. 1991: 2-Aza-anthraquinones as inhibitors of the Ca(2+)- and calmodulin-dependent cyclic adenosine 3',5'-monophosphate phosphodiesterase Die Pharmazie 46(4): 297-298
Kozhemiakin, L.A.; Korostovtsev, D.S.; Koroleva, T.R. 1978: Antihypoxic effect of analogs of cyclic adenosine monophosphate, phosphodiesterase inhibitors Farmakologiia i Toksikologiia 41(6): 711-714
Tronchet, J.M. 1973: Relationship between chemical structure and pharmacodynamic activity Pharmaceutica Acta Helvetiae 48(8): 482-488
Claro, A.; Grill, V.; Efendić, S.; Luft, R. 1977: Studies on the mechanisms of somatostatin action on insulin release. IV. effect of somatostatin on cyclic AMP levels and phosphodiesterase activity in isolated rat pancreatic islets Acta Endocrinologica 85(2): 379-388
Bonta, I.L.; Parnham, M.J.; Adolfs, M.J. 1979: Mimickry of anti-granuloma effect of prostaglandin e by dibutyryl cyclic-AMP and some phosphodiesterase inhibitors Agents and Actions. Supplements 4: 278-285
Kramer, G.L.; Wells, J.N. 1979: Effects of phosphodiesterase inhibitors on cyclic nucleotide levels and relaxation of pig coronary arteries Molecular Pharmacology 16(3): 813-822
Benigni, R. 2004: Chemical structure of mutagens and carcinogens and the relationship with biological activity Journal of Experimental and Clinical Cancer Research: Cr 23(1): 5-8
Liu, W.Q.; Zhuo, J.C.; Lei, X.P. 1983: Chemical structure-anticonvulsant activity relationship in beta-substituted cinnamamides Yao Xue Xue Bao 18(12): 912-919
Bai, A.P.; Guo, Z.R.; Chu, F.M. 2001: Three dimensional quantitative structure-activity relationship of heterocyclic-compounds with di-tert-bultylphenyl inhibitors Yao Xue Xue Bao 36(5): 347-350
Guluvob, S. 1972: Studies of the relationship between chemical structure and biological properties of the "O" antigens of gram negative bacteria Archives Roumaines de Pathologie Experimentales et de Microbiologie 31(3): 439-442
Cepelák, V.; Roubal, Z.; Kuchar, M. 1976: Fibrinolysis induction by synthetic organic acids. Chemical structure and biological activity relationship Folia Haematologica 103(3): 343-350
Zahavi, M.; Zahavi, J.; Kakkar, V.V. 1984: Effect of adenyl-cyclase activators, phosphodiesterase inhibitors and pyridoxal-5-phosphate on platelet aggregation and adenosine-3'-5'-cyclic monophosphate accumulation Thrombosis and Haemostasis 52(2): 205-209
Huang, N.; Chu, F.; Guo, Z. 1998: Studies on the structure-activity relationship of retinoids--Hansch analysis and 3D-OSAR studies on specific ligands of retinoid x receptor Yao Xue Xue Bao 33(6): 442-448