Morphological and cytochemical characteristics of human cells transformed and made malignant by Rous and polyoma viruses
Karazhas, N.V.; Shevliagin, V.Ia.; Amchenkova, A.M.
Tsitologiia 17(7): 829-834
1975
ISSN/ISBN: 0041-3771 PMID: 169614 Document Number: 85196
In cells of human embryo skin--muscle tissue transformed by the Rouse sarcoma virus (23rd cell line) and polyoma virus (P-2 cell line), the mitotic activity was 48 0/00 for 23rd line, 51 0/00 for P-2 line as against 28 0/00 in the control cells. The transformed cells possessed greater amounts of RNA and DNA and protein--bound SH-groups, different forms of glycogen deposits, as well as higher acid phosphatase enzyme activities; there was practically no difference in acid mucopolysaccharide content or NAD-H2-diaphorase and succinate dehydrogenase activities.