Clinical studies on anticholinergic drugs using intragastric pH meter
Penny, J.L.; Bonanno, C.; Grace, W.J.
Current Therapeutic Research 4: 258-262
1962
ISSN/ISBN: 0011-393X PMID: 14485134 Document Number: 8507
This study was carried out on 30 patients by using an intragastric electrode on a long nasogastric wire attached to a Beckman pH meter. Continuous pH readings and responses were recorded. (1) In 10 patients both propantheline bromide (Probanthine) and oxyphencyclimine hydrochloride (Daricon) were found to be potent in about 60 per cent of the patients. (2) The effect of histamine was not blocked by either drug. (3) In N additional patients oxyphencyclimine effectively raised the pH in 80 per cent of the patients and had a prolonged 8-hour effect in 35 per cent. (4) Stimulation of gastric secretion by food and emotional tension was not blocked by oxyphencyclimine. (5) Cigarette smoking had no effect on gastric pH. The results of this study indicate significant anticholinergic potency and moderately prolonged action of oxyphencyclimine. Further studies on peptic ulcer disease using the intragastric electrode and pH meter are in progress.
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