Influence of beta adrenergic blockers and their combinations with anticholinergic drugs on epileptiform activity in rabbit hippocampus
Tkatchenko, E.I.; Lossev, N.A.; Kästner, I.; Seidel, J.
Biomedica Biochimica Acta 46(5): 429-432
1987
ISSN/ISBN: 0232-766X PMID: 2889452 Document Number: 289031
The influence of .alpha.- and .beta.-receptor antagonists combined with drugs which act as antagonists at muscarinic and nicotinic receptor sites on epileptic focus produced by topic penicillin application was investigated. The .beta.-receptor blocking agent caused a faster and more intense activity of epileptogenic focus in comparison with activity in control animals, but the number of seizures decreased relatively for 25%. N-receptor antagonists diminished the facilitating effect of the .beta.-receptor antagonist on focal activity. Combination of m- and .beta.-receptor antagonists did not influence the spike activity of the focus. Treatment with alpha-receptor anbtagonists enhanced spikes and number of seizures only insignificantly. The combination of .alpha. and n-receptor blocking substances does not influence the development of the epileptic process. The .alpha.-receptor antagonist together with the m-receptor blocking drug induces a facilitation of spike activity.