The effect of sympatholytics and adrenergic receptor blockade on the histophysiology of the insular apparatus of the pancreas and insulin sensitivity of white rats
Sanduliak, L.I.; Mel'nik, T.F.
Problemy Endokrinologii 21(2): 96-100
1975
ISSN/ISBN: 0375-9660 PMID: 1093161 Document Number: 85036
Experiments were conducted on 200 male albino rats. It was shown that prolonged administration of sympatholytics (ornide or actadine) and also of a blocker of the alpha-adrenorecptors with phentholamine or of beta-adrenoreceptors with inderal led to the accumulation of zinc in the cytoplasm of beta-cells, reduction of the content in them of specific aldehyde-fuchsinophilic granularity, neoformation of the islands of Langerhans and to increase in the animal sensitivity to the exogenous insulin.