An approach to experimental scleroderma, using urinary glycosaminoglycans from patients with systemic scleroderma
Ishikawa, H.; Suzuki, S.; Horiuchi, R.; Sato, H.
Acta Dermato-Venereologica 55(2): 97-107
1975
ISSN/ISBN: 0001-5555 PMID: 48324 Document Number: 85035
As a result of intraperitoneal injections in mice of crude glycosaminoglycans obtained from the urine of patients with systemic scleroderma, a fibrotic process similar to the intial changes of human scleroderma was frequently observed, especially in the skin and esophagus when the glycosaminoglycans contained a probable variant of heparan sulfate. Furthermore, the scleroderma-like change was also observed, to some extent, in the ultrastructure of collagen fibers and glycosaminoglycans of the skin.