Antihypertensive activity of erythro-1- (1-[2- (1,4-benzodioxan-2-yl) -2-OH-ET]-4-piperidyl) -2-benzimidazolinone (R 28935)
Wellens, D.; Snoeckx, L.; De Reese, R.; Kruger, R.; Van de Water, A.; Woutens, L.; Reneman, R.S.
Archives Internationales de Pharmacodynamie et de Therapie 215(1): 119-132
1975
ISSN/ISBN: 0003-9780 PMID: 1156041 Document Number: 83168
Erythro-1-(1-[2-(1,4-benzodioxan-2-yl)-2-OH-ET]-4-piperidyl)-2-benzimidazolinone (R 28935), provokes marked antihypertensive effects lasting several hours in conscious SHR (0.63 to 40 mg/kg i.p.) and beagles with renal hypertension (1.25 mg/kg p.o.). In SHR, this compound induces much less bradycardia, compared to equiactive hypotensive doses of clonidine, guanethidine and propranolol. Significant postural hypotension during tilting, is induced by guanethidine and mecamylamine but not by R 28935. In anaesthetized beagles with renal hypertension, the lowering of the blood pressure by R 28935, (0.02-0.64 mg/kg i.v.) is associated with a considerable decrease in the total peripheral vascular resistance, whereas the myocardial function is not affected. R 28935 is considered a potent antihypertensive drug, with attractive haemodynamic characteristics.