T-lymphocyte control over the proliferative activity of committed precursor cells of erythro- and granulomonocytopoesis in stress
Dygaĭ, A.M.; Shakhov, V.P.; Gol'dberg, E.D.
Biulleten' Eksperimental'noi Biologii i Meditsiny 110(11): 531-533
1990
ISSN/ISBN: 0365-9615 PMID: 2083339 Document Number: 367153
The role of T-lymphocytes in regulation of proliferation and differentiation processes of committed myelopoiesis cell precursors in F1 (CBA-C57Bl/6) mice, treated by 10-hour immobilization was studied. One of the first reactions of hemopoietic precursors at stress was estimated to be the increase of active proliferating cells-precursors, accompanied by the quantitative changes of their content. The creation of T-cell deficit by means of anti-thymic serum resulted in abolition of the above mentioned changes of erythroid and granulo-macrophage precursors marked in the processes of adaptation syndrome development.