Metabolic repercussion of coenzyme-A (CoA) in experimental ethanol hepatopathy
Santos-Ruiz, A.; Cascales, C.; Martín-Sanz, P.; Cascales, M.
Acta Vitaminologica et Enzymologica 4(1-2): 69-80
1982
ISSN/ISBN: 0300-8924 PMID: 7124569 Document Number: 83
Rats were given a diet with 45% of total energy as plant oil and 15% ethanol as only source of liquid for 3 months. They were given coenzyme A 1 mg/kg bodyweight intraperitoneally daily. Enzyme activities were estimated in the soluble fraction of liver homogenates. Coenzyme A significantly increased the activity of malic enzyme, citrate lyase and 6-phosphogluconate dehydrogenase. Fatty acid synthetase and glycolytic kinase activity, which was decreased by the diet high in fat, was not increased by ethanol or coenzyme A.
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