Top Abstract Purchase Preview Related
Home
>
Node
>
Subnode

The protective action of a combination of essentiale with diethylnicotinamid on rat liver mono-oxygenases and glucuronyl- and glutathione transferases in a trichloromethane lesion

Bushma, M.I.; Legon'kova, L.F.; Zavodnik, L.B.; Zverinskiĭ, I.V.; Lukienko, P.I.

Eksperimental'naia i Klinicheskaia Farmakologiia 57(4): 62-63

1994

ISSN/ISBN: 0869-2092
PMID: 7950792
Document Number: 7879
The administration of 50% oil solution of essentiale to rats with carbon tetrachloride-induced hepatitis suppressed the inhibitory effect of CCl-4 on NADPH-cytochrome P-450, NADH-cytochrome-b-5-reductase and UDP-glucuronyl transferase activities as well as reduced ethylmorphine N-demethylation rate in liver microsomes. Addition of diethylnicotinamide to essentiale increased the enzyme-protective effect of the latter.

Document emailed within 1 workday
Secure & encrypted payments

The protective action of a combination of essentiale with diethylnicotinamid on rat liver mono-oxygenases and glucuronyl- and glutathione transferases in a trichloromethane lesion

Smith, G.J.; Ohl, V.S.; Litwack, G. 1980: Purification and properties of hamster liver ligandins, glutathione S-transferases Cancer Research 40(6): 1787-1790
Ublacker, G.A.; Johnson, J.A.; Siegel, F.L.; Mulcahy, R.T. 1991: Influence of glutathione S-transferases on cellular glutathione determination by flow cytometry using monochlorobimane Cancer Research 51(7): 1783-1788
Dierickx, P.J.; Almar, M.M.; De Jonckheere, J.F. 1990: Glutathione transferase activity in some flagellates and amoebae, and purification of the soluble glutathione transferases from Acanthamoeba Biochemistry International 22(4): 593-600
Scott, T.R.; Kirsch, R.E. 1991: Glutathione S-transferases YcYfetus and YcYc--kinetic and inhibitor studies relating to their glutathione peroxidase activities South African Medical Journal 79(6): 298-301
Cmarik, J.L.; Inskeep, P.B.; Meredith, M.J.; Meyer, D.J.; Ketterer, B.; Guengerich, F.P. 1990: Selectivity of rat and human glutathione S-transferases in activation of ethylene dibromide by glutathione conjugation and DNA binding and induction of unscheduled DNA synthesis in human hepatocytes Cancer Research 50(9): 2747-2752
Luk'ianchuk, V.D.; Savchenkoa, L.V.; Novosel'tseva, N.V. 1995: The mono-oxygenase system as a target in the action of hypoxia in combination with hyperthermia Likars'ka Sprava 1995(5-6): 100-102
Griffin, M.J.; Kirsten, E.; Carubelli, R.; Palakodety, R.B.; Mclick, J.; Kun, E. 1984: The in vivo effect of benzamide and phenobarbital on liver enzymes: poly(ADP-ribose) polymerase, cytochrome P-450, styrene oxide hydrolase, cholesterol oxide hydrolase, glutathione S-transferase and UDP-glucuronyl transferase Biochemical and Biophysical Research Communications 122(2): 770-775
Robertson, I.G.; Guthenberg, C.; Mannervik, B.; Jernström, B. 1986: Differences in stereoselectivity and catalytic efficiency of three human glutathione transferases in the conjugation of glutathione with 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene Cancer Research 46(5): 2220-2224
Takahashi, Y.; Niitsu, Y. 1994: Glutathione S transferases-pi Gan to Kagaku Ryoho. Cancer and ChemoTherapy 21(7): 945-951
Anttila, S.; Hirvonen, A.; Vainio, H.; Husgafvel-Pursiainen, K.; Hayes, J.D.; Ketterer, B. 1993: Immunohistochemical localization of glutathione S-transferases in human lung Cancer Research 53(23): 5643-5648
Mikstacka, R. 1988: The role of glutathione transferases in inactivation of carcinogenic compounds Postepy Biochemii 34(1-2): 47-57
Baars, A.J.; Breimer, D.D. 1980: The glutathione S-transferases: their role in detoxification and toxification of xenobiotics Annales de Biologie Clinique 38(1): 49-56
Cook, J.A.; Iype, S.N.; Mitchell, J.B. 1991: Differential specificity of monochlorobimane for isozymes of human and rodent glutathione S-transferases Cancer Research 51(6): 1606-1612
Board, P.G.; Chelvanayagam, G.; Jermiin, L.S.; Tetlow, N.; Tzeng, H.F.; Anders, M.W.; Blackburn, A.C. 2001: Identification of novel glutathione transferases and polymorphic variants by expressed sequence tag database analysis Drug Metabolism and Disposition: the Biological Fate of Chemicals 29(4 Pt 2): 544-547
Salagovic, J.; Kalina, I.; Stubna, J.; Habalová, V.; Hrivnák, M.; Valanský, L.; Kohút, A.; Biros, E. 1998: Genetic polymorphism of glutathione S-transferases M1 and T1 as a risk factor in lung and bladder cancers Neoplasma 45(5): 312-317
Legon'kova, L.F.; Abakumov, G.Z.; Bushma, M.I.; Lukienko, P.I. 1990: Changes in UDP-glucuronosyl-, glutathione-S-transferase and lipid peroxidation in rat liver microsomes during gamma-irradiation and protective effect of alpha-tocopherol Voprosy Meditsinskoi Khimii 36(3): 26-28
Molochkina, E.M.; Kaipova, G.D.; Papin, A.A.; Korotkina, R.N.; Karelin, A.A. 1985: The role of changes in the antioxidative activity and phospholipid composition of the rat liver in the mechanism of phenazepam action on the liver and the protective effect of talamonal Voprosy Meditsinskoi Khimii 31(3): 17-21
Marie, J.P.; Simonin, G.; Legrand, O.; Delmer, A.; Faussat, A.M.; Lewis, A.D.; Sikic, B.I.; Zittoun, R. 1995: Glutathione-S-transferases pi, alpha, mu and mdr1 mRNA expression in normal lymphocytes and chronic lymphocytic leukemia Leukemia 9(10): 1742-1747
Hayes, J.D.; McLeod, R.; Ellis, E.M.; Pulford, D.J.; Ireland, L.S.; McLellan, L.I.; Judah, D.J.; Manson, M.M.; Neal, G.E. 1996: Regulation of glutathione S-transferases and aldehyde reductase by chemoprotectors: studies of mechanisms responsible for inducible resistance to aflatoxin B1 Iarc Scientific Publications 139: 175-187
Peters, W.H.; Roelofs, H.M. 1992: Biochemical characterization of resistance to mitoxantrone and adriamycin in Caco-2 human colon adenocarcinoma cells: a possible role for glutathione S-transferases Cancer Research 52(7): 1886-1890