The efficacy of emoxipin and neoton in unstable stenocardia
Golikov, A.P.; Riabinin, V.A.; Golikov, P.P.; Davydov, B.V.; Polumiskov, V.I.; Rudnev, D.V.; Taranova, Z.V.
Terapevticheskii Arkhiv 68(1): 31-33
1996
ISSN/ISBN: 0040-3660 PMID: 8644026 Document Number: 7802
55 patients with unstable angina pectoris (group 1) received conventional treatment and neoton infusions (30 g/day for 3 days). Emoxipin was injected intramuscularly to 20 patients of group 2 (3 mg/kg for 20 days) and intravenously to 38 patients of group 3 (10 mg/kg). Control group consisted of 100 patients. Stabilization occurred in 89.2, 80 and 86.8% of group 1, 2 and 3 patients, respectively, versus 78% in controls. Holter ECG monitoring provided evidence on decline of myocardial ischemia for group 1 patients. Diene conjugates in group 1 decreased by 37%, ceruloplasmin level was higher by 30% compared to controls. Respective indices for emoxipin reached 52 and 37%, respectively. It is concluded that emoxipin and neoton produced a beneficial effect on unstable angina pectoris through correction of lipid peroxidation.
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